402 research outputs found
Supporting Accurate Interpretation of Self-Administered Medical Test Results for Mobile Health: Assessment of Design, Demographics, and Health Condition
Background: Technological advances in personal informatics allow people to track their own health in a variety of ways, representing a dramatic change in individuals’ control of their own wellness. However, research regarding patient interpretation of traditional medical tests highlights the risks in making complex medical data available to a general audience.
Objective: This study aimed to explore how people interpret medical test results, examined in the context of a mobile blood testing system developed to enable self-care and health management.
Methods: In a preliminary investigation and main study, we presented 27 and 303 adults, respectively, with hypothetical results from several blood tests via one of the several mobile interface designs: a number representing the raw measurement of the tested biomarker, natural language text indicating whether the biomarker’s level was low or high, or a one-dimensional chart illustrating this level along a low-healthy axis. We measured respondents’ correctness in evaluating these results and their confidence in their interpretations. Participants also told us about any follow-up actions they would take based on the result and how they envisioned, generally, using our proposed personal health system.
Results: We find that a majority of participants (242/328, 73.8%) were accurate in their interpretations of their diagnostic results. However, 135 of 328 participants (41.1%) expressed uncertainty and confusion about their ability to correctly interpret these results. We also find that demographics and interface design can impact interpretation accuracy, including false confidence, which we define as a respondent having above average confidence despite interpreting a result inaccurately. Specifically, participants who saw a natural language design were the least likely (421.47 times, P=.02) to exhibit false confidence, and women who saw a graph design were less likely (8.67 times, P=.04) to have false confidence. On the other hand, false confidence was more likely among participants who self-identified as Asian (25.30 times, P=.02), white (13.99 times, P=.01), and Hispanic (6.19 times, P=.04). Finally, with the natural language design, participants who were more educated were, for each one-unit increase in education level, more likely (3.06 times, P=.02) to have false confidence.
Conclusions: Our findings illustrate both promises and challenges of interpreting medical data outside of a clinical setting and suggest instances where personal informatics may be inappropriate. In surfacing these tensions, we outline concrete interface design strategies that are more sensitive to users’ capabilities and conditions
A Survey of Operations Research and Analytics Literature Related to Anti-Human Trafficking
Human trafficking is a compound social, economic, and human rights issue
occurring in all regions of the world. Understanding and addressing such a
complex crime requires effort from multiple domains and perspectives. As of
this writing, no systematic review exists of the Operations Research and
Analytics literature applied to the domain of human trafficking. The purpose of
this work is to fill this gap through a systematic literature review. Studies
matching our search criteria were found ranging from 2010 to March 2021. These
studies were gathered and analyzed to help answer the following three research
questions: (i) What aspects of human trafficking are being studied by
Operations Research and Analytics researchers? (ii) What Operations Research
and Analytics methods are being applied in the anti-human trafficking domain?
and (iii) What are the existing research gaps associated with (i) and (ii)? By
answering these questions, we illuminate the extent to which these topics have
been addressed in the literature, as well as inform future research
opportunities in applying analytical methods to advance the fight against human
trafficking.Comment: 28 pages, 6 Figures, 2 Table
Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity
Cauliflower mosaic virus (CaMV) encodes a multifunctional protein P6 that is required for translation of the 35S RNA and also acts as a suppressor of RNA silencing. Here we demonstrate that P6 additionally acts as a pathogenicity effector of an unique and novel type, modifying NPR1 (a key regulator of salicylic acid (SA)- and jasmonic acid (JA)-dependent signaling) and inhibiting SA-dependent defence responses We find that that transgene-mediated expression of P6 in Arabidopsis and transient expression in Nicotiana benthamiana has profound effects on defence signaling, suppressing expression of representative SA-responsive genes and increasing expression of representative JA-responsive genes. Relative to wild-type Arabidopsis P6-expressing transgenics had greatly reduced expression of PR-1 following SA-treatment, infection by CaMV or inoculation with an avirulent bacterial pathogen Pseudomonas syringae pv tomato (Pst). Similarly transient expression in Nicotiana benthamiana of P6 (including a mutant form defective in translational transactivation activity) suppressed PR-1a transcript accumulation in response to Agrobacterium infiltration and following SA-treatment. As well as suppressing the expression of representative SA-regulated genes, P6-transgenic Arabidopsis showed greatly enhanced susceptibility to both virulent and avirulent Pst (titres elevated 10 to 30-fold compared to non-transgenic controls) but reduced susceptibility to the necrotrophic fungus Botrytis cinerea. Necrosis following SA-treatment or inoculation with avirulent Pst was reduced and delayed in P6-transgenics. NPR1 an important regulator of SA/JA crosstalk, was more highly expressed in the presence of P6 and introduction of the P6 transgene into a transgenic line expressing an NPR1:GFP fusion resulted in greatly increased fluorescence in nuclei even in the absence of SA. Thus in the presence of P6 an inactive form of NPR1 is mislocalized in the nucleus even in uninduced plants. These results demonstrate that P6 is a new type of pathogenicity effector protein that enhances susceptibility to biotrophic pathogens by suppressing SA- but enhancing JA-signaling responses
Improving Access to Housing and Supportive Services for Runaway and Homeless Youth: Reducing Vulnerability to Human Trafficking in New York City
Recent estimates indicate that there are over 1 million runaway and homeless
youth and young adults (RHY) in the United States (US). Exposure to trauma,
violence, and substance abuse, coupled with a lack of community support
services, puts homeless youth at high risk of being exploited and trafficked.
Although access to safe housing and supportive services such as physical and
mental healthcare is an effective response to youths vulnerability towards
being trafficked, the number of youth experiencing homelessness exceeds the
capacity of available housing resources in most US communities. We undertake a
RHY-informed, systematic, and data driven approach to project the collective
capacity required by service providers to adequately meet the needs of homeless
youth in New York City, including those most at risk of being trafficked. Our
approach involves an integer linear programming model that extends the multiple
multidimensional knapsack problem and is informed by partnerships with key
stakeholders. The mathematical model allows for time-dependent allocation and
capacity expansion, while incorporating stochastic youth arrivals and length of
stays, services provided in a periodic fashion, and service delivery time
windows. Our RHY and service provider-centered approach is an important step
toward meeting the actual, rather than presumed, survival needs of vulnerable
youth, particularly those at-risk of being trafficked
The Influence of Self-efficacy on The Relationship Between Depression and HIV-related Stigma with ART Adherence Among The Youth in Malawi
 Depression and HIV-related stigma, among other factors, have been inversely linked independently with adherence to antiretroviral therapy (ART) among the youth. However, the processes through which the various factors influence this relationship is not fully known. Guided by Social Action Theory, we examined the interactive mechanisms through which depression, HIV-related stigma, and self-efficacy influenced ART adherence and whether or not these relationships are moderated by gender. A total of 450 HIV-positive youth (13–24 years) in Malawi receiving ART participated in this cross-sectional study. Moderated mediation analyses were conducted using Hayes’ PROCESS macro 2.11 in SPSS. ART adherence was measured by pill count. Findings showed that self-efficacy mediated the effects of depression and stigma on ART adherence. The analyses also revealed that gender moderated both the direct and indirect influence of depression and stigma (via self-efficacy) on ART adherence. Furthermore, self-efficacy simultaneously mediated and moderated the relationship between stigma and ART adherence. The interactive mechanisms through which various factors influence ART nonadherence must be considered to design effective interventions. To reduce the impact of depression and stigma on ART adherence, medication self-efficacy should be bolstered while taking gender in consideration. Keywords: Adolescent, Antiretroviral adherence, Malawi, Moderated mediation, Social action theory, Youth Abstrak Pengaruh Efikasi Diri Terhadap Hubungan antara Depresi dan Stigma HIV dengan Kepatuhan Terapi ART pada Remaja di Malawi. Depresi dan stigma HIV, di antara faktor-faktor lain, berhubungan terbalik secara independen dengan kepatuhan terapi antiretroviral (ART) pada remaja. Akan tetapi, dalam prosesnya faktor yang memengaruhi hubungan ini belum sepenuhnya diketahui. Berdasarkan Teori Perilaku Sosial, penelitian ini dilakukan bertujuan untuk mengkaji mekanisme interaktif depresi, stigma HIV, dan efikasi diri yang memengaruhi kepatuhan ART, dan untuk mengetahui apakah hubungan ini dimoderasi oleh gender atau tidak. Sebanyak 450 remaja dengan HIV-positif (13–24 tahun) di Malawi yang menerima ART ikut berpartisipasi dalam penelitian potong lintang ini. Analisis mediasi moderated dilakukan dengan menggunakan Hayes 'PROCESS macro 2.11 pada SPSS. Kepatuhan ART diukur menggunakan jumlah pil. Hasil penelitian menunjukkan bahwa efikasi diri memediasi efek depresi dan stigma pada kepatuhan ART. Hasil analisis juga mengungkapkan bahwa jenis kelamin memoderasi pengaruh langsung dan tidak langsung dari depresi dan stigma (melalui efikasi diri) terhadap kepatuhan ART. Lebih lanjut,efikasi diri secara bersamaan mediasi dan moderasi hubungan antara stigma dan kepatuhan ART. Mekanisme interaktif dengan berbagai faktor yang memengaruhi ketidakpatuhan ART harus dipertimbangkan untuk merancang intervensi yang efektif. Untuk mengurangi dampak depresi dan stigma terhadap kepatuhan ART, efikasi diri pengobatan harus didukung saat mempertimbangkan jenis kelamin. Kata kunci: Kepatuhan antiretroviral, Malawi, Mediasi tingkat menengah, Teori Perilaku Sosial, Remaj
On the Optimization of Benefit to Cost Ratios for Public Sector Decision Making
Decision making in the public sector centers on delivering resources and
services for the common good, emphasizing an expansive set of objectives such
as equity and efficiency, beyond immediate short term returns to reflect the
broader cares of society and public beneficiaries. Cost-benefit analysis is a
prevailing decision-making framework in the public sector that often uses the
benefit to cost ratio (BCR) to compare viable alternatives, yet no systematic
framework exists for evaluating many alternatives beyond the status quo of
doing nothing. We propose a new framework to maximize the BCR for public sector
decisions, seeking the largest improvement per marginal deployment of capacity.
Requiring a status quo representable through (constrained) decision variables,
the framework is generally applicable and useful to a broad set of decision
contexts that involve maximizing the BCR for marginal deployments of resources.
We demonstrate the applicability of our framework on a compelling case study
for the New York City runaway and homeless youth shelter system, an area of
high societal need. We represent this problem as a mixed integer linear
fractional program (MILFP) and employ Dinkelbach's algorithm that converts the
MILFP to a series of linearized mixed-integer optimization problems, making our
approach tractable for fairly large problem instances. Our optimization-based
algorithmic framework yields data-informed recommendations for making New York
City shelter expansion decisions to better serve runaway and homeless youth,
and generalizes to reveal managerial insights for optimizing the BCR. More
broadly, our algorithmic decision making framework allows for iteration and
comparison across multiple potential constraints ensuring action away from the
status quo, thereby empowering effective assessment of marginal deployment of
additional resources
"Solid state charge trapping": Examples of polymer systems showing memory effect
The paper reports on a characteristic property of electroactive materials bearing an electron-rich and an electron-poor moiety, known as charge trapping. As examples of materials that exhibit this phenomenon, films of poly(4,4"-dipentoxy-4\u27-(2,2\u27-dicyano)ethenyl-2,2\u27:5\u27,2"-terthiophene), poly(2,3-dihexylthieno[3,4-b]pyrazine) and a blend between a fulleropyrrolidine derivative and poly(3-hexylthiophene) were investigated by cyclic voltammetry, spectroelectrochemistry and electrochemical quartz crystal microbalance. In the cyclic voltammetry, the reduction processes show the reverse oxidation potential about 1 V higher than the expected value, indicating a strong stabilization of the corresponding anion species. The mechanism leading to the stabilisation of the anions is discussed and the results indicate that the investigated materials exhibit a remarkable and quite stable memory effect
Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling
Cauliflower mosaic virus (CaMV) encodes a 520 aa polypeptide, P6, which participates in several essential activities in the virus life cycle including suppressing RNA silencing and salicylic acid-responsive defence signalling. We infected Arabidopsis with CaMV mutants containing short in-frame deletions within the P6 ORF. A deletion in the distal end of domain D-I (the N-terminal 112 aa) of P6 did not affect virus replication but compromised symptom development and curtailed the ability to restore GFP fluorescence in a GFP-silenced transgenic Arabidopsis line. A deletion in the minimum transactivator domain was defective in virus replication but retained the capacity to suppress RNA silencing locally. Symptom expression in CaMV-infected plants is apparently linked to the ability to suppress RNA silencing. When transiently co-expressed with tomato bushy stunt virus P19, an elicitor of programmed cell death in Nicotiana tabacum, WT P6 suppressed the hypersensitive response, but three mutants, two with deletions within the distal end of domain D-I and one involving the N-terminal nuclear export signal (NES), were unable to do so. Deleting the N-terminal 20 aa also abolished the suppression of pathogen-associated molecular pattern-dependent PR1a expression following agroinfiltration. However, the two other deletions in domain D-I retained this activity, evidence that the mechanisms underlying these functions are not identical. The D-I domain of P6 when expressed alone failed to suppress either cell death or PR1a expression and is therefore necessary but not sufficient for all three defence suppression activities. Consequently, concerns about the biosafety of genetically modified crops carrying truncated ORFVI sequences appear unfounded
Estimating Effectiveness of Identifying Human Trafficking via Data Envelopment Analysis
Transit monitoring is a preventative approach used to identify possible cases
of human trafficking while an individual is in transit or before one crosses a
border. Transit monitoring is often conducted by non-governmental organizations
(NGOs) who train staff to identify and intercept suspicious activity. Love
Justice International (LJI) is one such NGO that has been conducting transit
monitoring for 14 years along the Nepal-India border at approximately 25-30
monitoring stations. In partnership with LJI, we developed a system that uses
data envelopment analysis (DEA) to help LJI decision-makers evaluate the
performance of these stations and make specific operational improvement
recommendations. We identified efficient stations, compared rankings of station
performance, and recommended strategies to improve efficiency. To the best of
our knowledge, this is the first application of DEA in the anti-human
trafficking domain
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